Ph.D. thesis
Full document
My Ph.D. thesis is published through Heidelberg University Library and can be downloaded here.Videos of computational model simulations
During my PhD, we have published a computational model for describing intra-crypt dynamics at early steps of colorectal carcinogenesis in Lynch syndrome. Some videos of the numerical simulation results are shown here.Video 1: Loss of MMR deficiency after stem cell exchange
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Video 2: Exponential expansion of biallelically APC-mutated cells
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Video 3: Exponential expansion and monoclonal conversion of biallelically CTNNB1-mutated cells
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Video 4: Limited spread of APC mutations in an MMR-deficient crypt
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Video 5: Successful spread of an APC mutation in an MMR-deficient crypt
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Video 6: Prolonged monoclonal conversion of an MMR stem cell mutation
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Video 7: Top-down morphogenesis of a biallelically APC-mutated crypt
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Video 8: Bottom-up morphogenesis of a biallelically APC-mutated crypt
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